SPRAVATO® is the only FDA-approved nasal spray specifically designed for Treatment-Resistant Depression. This prescription medication is used in combination with an oral antidepressant to treat adults with treatment-resistant depression (TRD), as well as depressive symptoms in adults with major depressive disorder (MDD) who are experiencing suicidal thoughts or actions.
Unlock the potential of Spravato treatment at Three Rivers Wellness in Gallatin, Tennessee. Take the first step toward a brighter future by scheduling your consultation today. Your journey to relief starts here—contact us now!
Spravato® is administered via nasal spray, making it convenient and non-invasive. You can comfortably receive your treatment in our clinic under the supervision of our trained professionals.
Many insurance plans cover Spravato®, making this groundbreaking treatment accessible to more patients. Our team can help you verify insurance and navigate the coverage process.
Spravato® (esketamine) is a prescription nasal spray that works as an antidepressant by targeting the brain’s glutamate system. Unlike traditional antidepressants, which often take weeks to show effects, Spravato® can begin to work within hours.
When administered, Spravato® binds to NMDA receptors in the brain, leading to an increase in glutamate release. Glutamate is a neurotransmitter that plays a critical role in neural activation and synaptic plasticity, which are essential for mood regulation and cognitive functions. This increase in glutamate helps to create new neural connections, improving communication between brain cells.

Your journey at Three Rivers Wellness begins with a thorough evaluation conducted by our skilled mental health professionals. We will review your medical history, assess your current symptoms, and examine previous treatment outcomes to determine if ketamine is a suitable option for you.
Spravato, a distinct form of ketamine from that used in IV ketamine infusions, differs in both administration and results. At Three Rivers Wellness, we will explain these differences and assist you in selecting the most appropriate option based on your individual needs and goals.

At Three Rivers Wellness, Spravato® is administered through a series of sessions. The initial phase involves twice-weekly treatments for four weeks, followed by a maintenance phase, which typically consists of one treatment weekly or every other week.
Each session takes place in our comfortable, private treatment rooms, allowing you to relax under the attentive care of our dedicated staff. Each treatment session lasts two hours, and it is necessary to arrange for a driver to take you home afterwards.

At Three Rivers Wellness in Gallatin, TN, our dedicated team meticulously tracks your progress throughout every stage of your treatment. We understand that each individual’s response to treatment can vary, so we continuously evaluate your condition and make any necessary adjustments to your personalized plan.
We provide comprehensive, ongoing support to ensure you achieve the best possible outcomes. Additionally, we are always available to address any questions or concerns you may have, ensuring that you feel fully supported throughout your entire treatment journey.
Spravato® (esketamine) is a groundbreaking treatment that has revolutionized the management of treatment-resistant depression (TRD). Unlike traditional antidepressants that can take weeks to show effects, Spravato® works rapidly, offering relief from depressive symptoms within hours to days. Administered as a nasal spray under the supervision of a healthcare professional, it targets the NMDA receptors in the brain, a different mechanism than most antidepressants, which helps to alleviate severe depression symptoms when other treatments have failed. This rapid action is crucial for individuals suffering from severe depression, as it can significantly reduce the risk of suicide and improve the overall quality of life.
Additionally, Spravato® is beneficial because it offers an alternative for patients who have not responded well to conventional antidepressants. Its unique mechanism of action provides new hope for those who have struggled with depression for years without finding effective treatment. Moreover, the supervised administration process ensures patient safety and allows for close monitoring of any side effects, making it a viable option for those who need immediate relief but have concerns about medication management. Overall, Spravato® represents a significant advancement in depression treatment, providing fast, effective relief for individuals who need it the most.
The National Suicide Prevention Lifeline is a national network of local crisis centers that provides free and confidential emotional support to people in suicidal crisis or emotional distress 24 hours a day, 7 days a week in the United States.